The neuraminidases of the virulent and avirulent A/Chicken/Pennsylvania/ 83 (H5N2) influenza a viruses: Sequence and antigenic analyses
Identifieur interne : 000183 ( 1957/Analysis ); précédent : 000182; suivant : 000184The neuraminidases of the virulent and avirulent A/Chicken/Pennsylvania/ 83 (H5N2) influenza a viruses: Sequence and antigenic analyses
Auteurs : Kathryn L. Deshpande [États-Unis] ; Clayton W. Naeve [États-Unis] ; Robert G. Webster [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1985.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Conformation des protéines, Embryon de poulet, Gènes, Gènes viraux, Modèles moléculaires, Poulets, Sialidase (immunologie), Sialidase (isolement et purification), Sous-type H5N2 du virus de la grippe A, Spécificité d'espèce, Séquence d'acides aminés, Séquence nucléotidique, Virulence, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité), Épitopes (analyse).
- MESH :
- analyse : Épitopes.
- enzymologie : Virus de la grippe A.
- génétique : Virus de la grippe A.
- immunologie : Sialidase.
- isolement et purification : Sialidase.
- pathogénicité : Virus de la grippe A.
- Animaux, Anticorps monoclonaux, Conformation des protéines, Embryon de poulet, Gènes, Gènes viraux, Modèles moléculaires, Poulets, Sous-type H5N2 du virus de la grippe A, Spécificité d'espèce, Séquence d'acides aminés, Séquence nucléotidique, Virulence.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal, Base Sequence, Chick Embryo, Chickens, Epitopes (analysis), Genes, Genes, Viral, Influenza A Virus, H5N2 Subtype, Influenza A virus (enzymology), Influenza A virus (genetics), Influenza A virus (pathogenicity), Models, Molecular, Neuraminidase (immunology), Neuraminidase (isolation & purification), Protein Conformation, Species Specificity, Virulence.
- MESH :
- chemical , analysis : Epitopes.
- chemical , immunology : Neuraminidase.
- chemical , isolation & purification : Neuraminidase.
- enzymology : Influenza A virus.
- genetics : Influenza A virus.
- pathogenicity : Influenza A virus.
- Teeft :
- Acid deletion, Amino, Amino Acid Sequence, Amino acid, Amino acid change, Amino acid changes, Amino acid sequence, Amino acids, Animals, Antibodies, Monoclonal, Antigenic, Antigenic analysis, Antigenic sites, Antigenically, Avian, Avian influenza viruses, Avian source, Avian viruses, Avirulent, Base Sequence, Blok, Chick Embryo, Chickens, Deletion, Deshpande, Gene constellation, Genes, Genes, Viral, Hemagglutinin, Homology, Influenza, Influenza A Virus, H5N2 Subtype, Influenza virus, Influenza virus neuraminidase, Influenza viruses, Laver, Models, Molecular, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Naeve, Natl acad, Neuraminidase, Neuraminidase gene, Nucleotide, Nucleotide sequence, Other viruses, Protein Conformation, Rott, Scholtissek, Species Specificity, Viral, Viral membrane, Virology, Virulence, Virulent, Virulent chick, Virulent virus, Virulent viruses, Virus, Webster.
Abstract
Abstract: To define the sequence changes that occurred in an avian influenza virus neuraminidase (NA) during the evolution of virulence, we have studied the NA of the virulent and avirulent A/Chick/Penn/83 (H5N2) influenza viruses. A comparison of the deduced amino acid sequence from these viruses shows that the virulent strain, which evolved from the avirulent by the accumulation of point mutations (Bean et al., 1985), acquired four amino acid changes in the NA: one in the transmembrane segment, one in the stalk, and two in the head. A comparison of the deduced amino acid sequences with those of the human N2 NAs indicates a 20-amino acid deletion in the stalk of the Chick/Penn/83 NA. Antigenic analysis of the NAs from the avirulent and virulent Chick/Penn/83 virus shows they are antigenically very closely related, but can be distinguished with two monoclonal antibodies at a site which probably involves at least one of the amino acid changes in the NA head. Antigenic analysis also shows the Chick/Penn/83 NAs are closely related to the NAs of other N2 avian influenza viruses isolated between 1965 and 1984, supporting previous studies which indicate a relative antigenic stability of the NA among avian N2 influenza viruses. The Chick/Penn/83 NAs are the first N2 NA genes of an avian virus to be sequenced. These NAs are antigenically closely related to the 1957 human N2 NAs, and show a high degree of amino acid sequence homology with the prototype 1957 human N2 NA. These data give further support to the view that the 1957 human H2N2 viruses were at least partially derived from an avian source.
Url:
DOI: 10.1016/0042-6822(85)90226-0
Affiliations:
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ISTEX:98890D352E6201C3F1A934CF5C78E3B7B3C36F27Le document en format XML
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Box 318, Memphis, Tennessee 38101</wicri:regionArea><wicri:noRegion>Tennessee 38101</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">147</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Monoclonal</term><term>Base Sequence</term><term>Chick Embryo</term><term>Chickens</term><term>Epitopes (analysis)</term><term>Genes</term><term>Genes, Viral</term><term>Influenza A Virus, H5N2 Subtype</term><term>Influenza A virus (enzymology)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (pathogenicity)</term><term>Models, Molecular</term><term>Neuraminidase (immunology)</term><term>Neuraminidase (isolation & purification)</term><term>Protein Conformation</term><term>Species Specificity</term><term>Virulence</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Conformation des protéines</term><term>Embryon de poulet</term><term>Gènes</term><term>Gènes viraux</term><term>Modèles moléculaires</term><term>Poulets</term><term>Sialidase (immunologie)</term><term>Sialidase (isolement et purification)</term><term>Sous-type H5N2 du virus de la grippe A</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virulence</term><term>Virus de la grippe A (enzymologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (pathogénicité)</term><term>Épitopes (analyse)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" 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viruses</term><term>Virus</term><term>Webster</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Conformation des protéines</term><term>Embryon de poulet</term><term>Gènes</term><term>Gènes viraux</term><term>Modèles moléculaires</term><term>Poulets</term><term>Sous-type H5N2 du virus de la grippe A</term><term>Spécificité d'espèce</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term><term>Virulence</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: To define the sequence changes that occurred in an avian influenza virus neuraminidase (NA) during the evolution of virulence, we have studied the NA of the virulent and avirulent A/Chick/Penn/83 (H5N2) influenza viruses. A comparison of the deduced amino acid sequence from these viruses shows that the virulent strain, which evolved from the avirulent by the accumulation of point mutations (Bean et al., 1985), acquired four amino acid changes in the NA: one in the transmembrane segment, one in the stalk, and two in the head. A comparison of the deduced amino acid sequences with those of the human N2 NAs indicates a 20-amino acid deletion in the stalk of the Chick/Penn/83 NA. Antigenic analysis of the NAs from the avirulent and virulent Chick/Penn/83 virus shows they are antigenically very closely related, but can be distinguished with two monoclonal antibodies at a site which probably involves at least one of the amino acid changes in the NA head. Antigenic analysis also shows the Chick/Penn/83 NAs are closely related to the NAs of other N2 avian influenza viruses isolated between 1965 and 1984, supporting previous studies which indicate a relative antigenic stability of the NA among avian N2 influenza viruses. The Chick/Penn/83 NAs are the first N2 NA genes of an avian virus to be sequenced. These NAs are antigenically closely related to the 1957 human N2 NAs, and show a high degree of amino acid sequence homology with the prototype 1957 human N2 NA. These data give further support to the view that the 1957 human H2N2 viruses were at least partially derived from an avian source.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Deshpande, Kathryn L" sort="Deshpande, Kathryn L" uniqKey="Deshpande K" first="Kathryn L." last="Deshpande">Kathryn L. Deshpande</name></noRegion><name sortKey="Naeve, Clayton W" sort="Naeve, Clayton W" uniqKey="Naeve C" first="Clayton W." last="Naeve">Clayton W. Naeve</name><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G." last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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